In its first two and half years COLTHERES has achieved effective and clinically relevant results as demonstrated in the graphic below!
A .pdf file of the image can be downloaded here
Jun 102013
Apr 072013
COLTHERES Partner Horizon Discovery has two posters at the American Association of Cancer Research Annual meeting, April 6-10 2013. They are
3-Dimensional growth reveals KRAS dependency
and
X‐MAN™ reporter cell lines: Enabling the study ofendogenous promoter activity and protein dynamics
Mar 132013
COLTHERES partners have been published in the International Journal of Cancer. The article entitled
‘KRAS gene amplification in colorectal cancer and impact on response to EGFR-targeted therapy‘
can be found on the journal website here.
Mar 072013
COLTHERES partners Ospedale Niguarda Ca’ Granda and IDIBELL have had a joint paper entitled
published in Clinical Cancer Research. The full article is available here
Feb 012013
The COLTHERES results on Molecular Subtypes Signatures were presented at the 2013 American Society of Clinical Oncology Gastrointestinal Cancers Symposium (ASCO GI) in San Francisco. A poster was presented and the abstract was selected for oral presentation and for the ASCO press program. Several websites and newspapers picked up on the story and there have been several follow-up articles about the work.
The poster is available here.
An article on Medscape is available here (A Medscape account is required to view this).
For the ASCO press release and information please see here and here.
Nov 232012
Based on pre-clinical data generated partly within COLTHERES, the following trial has recently been initiated:
Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer
More information is available here. The COLTHERES pre-clinical data was reported here
Nov 102012
Horizon Discovery presented a poster at EORTC, with results from the COLTHERES project. You can download the poster here.
Jun 152012
COLTHERES partners have had a 2nd paper published in Nature, the 2nd in 3 months.
“Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer”
May 152012
Apr 152012
COLTHERES has presented in the session on
at the ‘American Association for Cancer Research‘ annual meeting in Chicago in April 2012