COLTHERES: Bench to Bed

In its first two and half years COLTHERES has achieved effective and clinically relevant results as demonstrated in the graphic below!


A .pdf file of the image can be downloaded here



The COLTHERES results on Molecular Subtypes Signatures were presented at the 2013 American Society of Clinical Oncology Gastrointestinal Cancers Symposium (ASCO GI) in San Francisco. A poster was presented and the abstract was selected for oral presentation and for the ASCO press program. Several websites and newspapers picked up on the story and there have been several follow-up articles about the work.

The poster is available here.

An article on Medscape is available here (A Medscape account is required to view this).

For the ASCO press release and information please see here and here.


Clinical Trial!

Based on pre-clinical data generated partly within COLTHERES, the following trial has recently been initiated:


Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer


More information is available here. The COLTHERES pre-clinical data was reported here